Latest papers

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.

High frequency transformation of the industrial erythromycin-producing bacterium Saccharopolyspora erythraea.

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of C-12 hydroxylase EryK from Saccharopolyspora erythraea.

The biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of the cross-bridging precursor and identification of the function of SpnJ.

Overexpression of GATA-3 protects against the development of hypersensitivity pneumonitis.

Assessment of four serological techniques in the immunological diagnosis of farmers' lung disease.

Use of phage battery to investigate the actinofloral layers of termite gut microflora.

Improved production of erythromycin A by expression of a heterologous gene encoding S-adenosylmethionine synthetase.

Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production

Antibiotic production from the ground up.

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.

Predicting the nature and timing of epimerisation on a modular polyketide synthase.

Engineering of the spinosyn PKS: directing starter unit incorporation.

Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis.

IL-4-secreting NKT cells prevent hypersensitivity pneumonitis by suppressing IFN-gamma-producing neutrophils.

Single amino acid substitutions alter the efficiency of docking in modular polyketide biosynthesis.

Glycine origin of the methyl substituent on C7'-N of octodiose for the biosynthesis of apramycin.

Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea.

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase.

Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.