Latest papers

Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir

Roche Labs update insert for saquinavir.

Double boosted protease inhibitors, saquinavir, and lopinavir/ritonavir, in nucleoside pretreated children at 48 weeks.

Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.

Invirase package insert updated.

Pharmacokinetic analysis to assess forgiveness of boosted saquinavir regimens for missed or late dosing.

Rate-limiting steps in hepatic drug clearance: comparison of hepatocellular uptake and metabolism with microsomal metabolism of saquinavir, nelfinavir, and ritonavir.

Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum.

Quality control of protease inhibitors.

Short communication: oral lesions in HIV/AIDS patients undergoing HAART including efavirenz.

Pharmacokinetics and safety of saquinavir/ritonavir and omeprazole in HIV-infected subjects.

Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy.

Differential roles of P-glycoprotein, multidrug resistance-associated protein 2, and CYP3A on saquinavir oral absorption in Sprague-Dawley rats.

An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat.

Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers.

Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.

In vitro phenotypic susceptibility of human immunodeficiency virus type 2 clinical isolates to protease inhibitors.

Saquinavir plus lopinavir/ritonavir versus amprenavir plus lopinavir/ritonavir for treating highly resistant patients in Brazil.

Electromagnetic interference in the permeability of saquinavir across the blood-brain barrier using nanoparticulate carriers.

Rapid and accurate prediction of binding free energies for saquinavir-bound HIV-1 proteases.