Latest papers

Differential activation of dual promoters alters Dbeta2 germline transcription during thymocyte development.

Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.

The ontogeny and fate of NK cells marked by permanent DNA rearrangements.

Modulation of RAG/DNA complex by HSP70 in V(D)J recombination

Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.

V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.

Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly.

ATM prevents unattended DNA double strand breaks on site and in generations to come.

Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretches.

DNA repair and the immune system: From V(D)J recombination to aging lymphocytes.

Targeting V(D)J Recombinase: Putting a PHD to Work

Induction of V(D)J-mediated recombination of an extrachromosomal substrate following exposure to DNA-damaging agents.

DNA-dependent protein kinase mediates V(D)J recombination via RAG2 phosphorylation.

Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV.

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.

V(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends.

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.