Latest papers

Syndrome-causing mutations in Werner syndrome.

Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.

Werner's Syndrome: A Rare Cause of Hoarseness

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.

Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome.

A novel mutation of the WRN gene in a Chinese patient with Werner syndrome.

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Different patterns of in vivo pro-oxidant states in a set of cancer- or aging-related genetic diseases.

Scleroderma-like disorders.

Werner syndrome helicase activity is essential in maintaining fragile site stability.

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.

Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.

Early amelioration of insulin resistance and reduction of interleukin-6 in Werner syndrome using pioglitazone.

[Premature aging syndromes : From phenotype to gene]

Delayed kinetics of DNA double-strand break processing in normal and pathological aging.

WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.

[The atypical of Werner syndrome: effect of laminopathy].