Latest papers

Hsp90 mediates activation of the heme regulated eIF-2 alpha kinase during oxidative stress.

Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection.

Molecular cloning and functional characterization of porcine DNA-dependent activator of IFN-regulatory factors (DAI).

The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.

The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV.

Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.

Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat.

Small-scale modeling approach and circuit wiring of the unfolded protein response in mammalian cells.

Host and viral translational mechanisms during cricket paralysis virus infection.

Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation.

Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus.

The roles of nitric oxide synthase and eIF2alpha kinases in regulation of cell cycle upon UVB-irradiation.

Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene Products

Multifaceted Evasion of the Interferon Response by Cytomegalovirus

Biochemical analysis of PKR activation by PACT.

Old target new approach: an alternate NF-kappaB activation pathway via translation inhibition.

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

RNA Dimerization Promotes PKR Dimerization and Activation

Immunotherapy of mycobacterial infections: a cell and molecular model.