Latest papers

p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo.

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin.

[Effects of epigallocatechin-3-gallate on the proliferation of colonic cancer cell line SW620 and PAK1 gene expression]

Cdc42GAP, reactive oxygen species, and the vimentin network.

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

Involvement of betaPIX in angiotensin II-induced migration of vascular smooth muscle cells.

A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.

Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration.

TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin

[Clinicopathological significance of expression and amplification of P21-activated kinase 1 gene in colorectal carcinoma]

Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.

Elevated p21-activated kinase 2 activity results in anchorage-independent growth and resistance to anticancer drug-induced cell death.

Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice.

14-3-3β-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly

The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.

Study of in vitro and in vivo effect of docosahexaenoic acid on rat C6 glioma.

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.

MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy.

PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival.