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  • Weighing Risks and Benefits of Postchemotherapy Retroperitoneal Lymph Node Dissection: Not So Easy.
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  • "I Am Older, Not Elderly," Said the Patient With Acute Myeloid Leukemia.
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  • Treatment of Older Patients With Non-Small-Cell Lung Cancer: Walking the Therapeutic Tightrope.
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  • Toward Efficient Trials in Colorectal Cancer: The ARCAD Clinical Trials Program.
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  • Long-Term Follow-Up of Cisplatin Combination Chemotherapy in Patients With Disseminated Nonseminomatous Germ Cell Tumors: Is a Postchemotherapy Retroperitoneal Lymph Node Dissection Needed After Complete Remission?
    One hundred forty-one patients were identified. Five patients (4%) had less than 2 years of follow-up. After a median follow-up of 1...
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  • Management of Disseminated Nonseminomatous Germ Cell Tumors With Risk-Based Chemotherapy Followed by Response-Guided Postchemotherapy Surgery.
    One hundred sixty-one patients achieved a CR. Results for the total population and CR subset were as follows: International Germ Cel...
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  • Randomized Phase III Trial on Gemcitabine Versus Mytomicin in Recurrent Superficial Bladder Cancer: Evaluation of Efficacy and Tolerance.
    A total of 120 patients were enrolled and randomly assigned to either the MMC or GEM treatment arm. At the end of the study, 109 pat...
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  • Phase II Study of Clofarabine Monotherapy in Previously Untreated Older Adults With Acute Myeloid Leukemia and Unfavorable Prognostic Factors.
    In 112 evaluable patients who were treated (median age, 71 years; range, 60 to 88 years), the ORR was 46% (38% CR, 8% CRp). ORR by u...
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  • Multicenter, Phase II Study of Decitabine for the First-Line Treatment of Older Patients With Acute Myeloid Leukemia.
    Fifty-five patients (mean age, 74 years) were enrolled and were treated with a median of three cycles (range, one to 25 cycles) of d...
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  • Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia.
    Of the 113 elderly patients (median age, 70 years) randomly assigned to receive azacitidine (n = 55) or CCR (n = 58; 47% BSC, 34% LD...
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  • Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical Outcome.
    Only patients with biCEBPA had an improved median overall survival when compared with patients with wtCEBPA (not reached v 20.4 mont...
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  • Single Nucleotide Polymorphism in the Mutational Hotspot of WT1 Predicts a Favorable Outcome in Patients With Cytogenetically Normal Acute Myeloid Leukemia.
    The minor allele of SNP rs16754 (WT1(AG/GG)) was found in 25.7% of CN-AML patients' blasts and germline DNA and in 36% of healthy vo...
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  • Attempts to Optimize Induction and Consolidation Treatment in Acute Myeloid Leukemia: Results of the MRC AML12 Trial.
    Complete remission (CR) was achieved in 74% of patients and CR without recovery was achieved in an additional 11%; overall survival...
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  • Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study.
    Patients with NPM1 mutations (56%) had higher complete remission (CR) rates (84% v 48%; P < .001) and longer disease-free survival (...
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  • DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes.
    In an initial training cohort of 89 patients with MDS, methylation frequencies of individual genes ranged from 7% to 70% and were hi...
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  • Phase II Trial of Pemetrexed Plus Bevacizumab for Second-Line Therapy of Patients With Advanced Non-Small-Cell Lung Cancer: NCCTG and SWOG Study N0426.
    Forty-eight evaluable patients (14 females and 34 males) received a median of four cycles (range, one to 20 cycles). The most common...
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  • Adverse Events Among the Elderly Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer.
    Of 1,371 patients, 58% (95% CI, 55% to 61%) received chemotherapy and 35% (95% CI, 32% to 38%) had AEs. After adjustment, 72% (95% C...
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  • Feasibility Trial of Letrozole in Combination With Bevacizumab in Patients With Metastatic Breast Cancer.
    Forty-three patients were treated. After a median of 13 cycles (range, 1 to 71 cycles), select treatment-related toxicities included...
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  • Acupuncture Versus Venlafaxine for the Management of Vasomotor Symptoms in Patients With Hormone Receptor-Positive Breast Cancer: A Randomized Controlled Trial.
    Both groups exhibited significant decreases in hot flashes, depressive symptoms, and other quality-of-life symptoms, including signi...
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  • Phase III, Randomized, Double-Blind, Placebo-Controlled Evaluation of Pregabalin for Alleviating Hot Flashes, N07C1.
    Hot flash score changes available for 163 patients during the sixth treatment week compared with a baseline week decreased by 50%, 6...
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  • Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study.
    Complete remission (CR) rates (mean +/- SE) were 83% +/- 4% for early first marrow relapse, 93% +/- 3% for late first marrow relapse...
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  • Suicide Ideation in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
    Of survivors, 7.8% reported SI compared with 4.6% of controls (odds ratio = 1.79; 95% CI, 1.4 to 2.4). Suicidality was unrelated to...
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  • Costs and Benefits of the National Cancer Institute Central Institutional Review Board.
    CIRB affiliation was associated with faster reviews (33.9 calendar days faster on average), and 6.1 fewer hours of research staff ef...
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  • Clinically Driven Diagnostic Antifungal Approach in Neutropenic Patients: A Prospective Feasibility Study.
    Of 220 neutropenia episodes, fever occurred in 159 cases and recurred in 28 cases. Overall, 49 IFDs were diagnosed (two by BDWU and...
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  • Preventing Future Cancers by Testing Women With Ovarian Cancer for BRCA Mutations.
    BRCA testing based on personal/family history and ancestry could prevent future cases in FDRs with an ICER of $32,018 per year of li...
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  • Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes.
    Of 215 patients, five (2.3%) had a pregnancy that ended in a spontaneous miscarriage and 30 (14.0%) pregnancies were interrupted. Tr...
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  • Smoldering (Asymptomatic) Multiple Myeloma: Current Diagnostic Criteria, New Predictors of Outcome, and Follow-Up Recommendations.
    The risk factors for progression of SMM include: plasma cell mass including M-protein size and percentage of bone marrow clonal plas...
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  • Sources of Bias in Specimens for Research About Molecular Markers for Cancer.
    Claims about the diagnostic or prognostic accuracy of markers often prove disappointing when "discrimination" found...
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  • Pessimism Is No Poison.
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  • Author Correction
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  • Extraosseous Pericardial Ewing's Sarcoma.
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  • T-Cell Lymphoblastic Lymphoma of the Sternum.
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  • Gastric Recurrence of Extramedullary Granulocytic Sarcoma After Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia.
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  • Findings That Hospital Factors Are Surrogate for Disparities Are Misleading.
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  • Reply to Q.D. Chu et al.
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  • Changes In PSA Kinetics After DNA Vaccine Therapy-Not So Fast!
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  • Reply to M.R. Smith et al.
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  • Breast Cancer Classification: The Dialogue Is Open.
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  • Reply to V. Arena et al.
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  • How Should We Prevent Hematologic Relapse of Acute Promyelocytic Leukemia?
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  • Reply to S. Nagai et al.
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