The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner.
Molecular Psychiatry (2017)
Disruption of the laminar and columnar organization of the brain is implicated in several psychiatric disorders. Here, we show in utero gain-of-function of the psychiatric risk gene transcription factor 4 (TCF4) severely disrupts the columnar organization of medial prefrontal cortex (mPFC) in a t...
Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression.
Progress in Neuro-Psychopharmacology and Biolog... 70:8 (2016)
Aggressive behavior is one of the most challenging symptoms in psychiatry, and biological markers for aggression lack of large sample validations. Serotonin (5-HT) and other neuroactive compounds deriving from Tryptophan (Trp), including kynurenine (Kyn), have not yet been investigated in large ...
Locating the Social Origins of Mental Illness: The Explanatory Models of Mental Illness Among Clergy from Different Ethnic and Faith Backgrounds.
Journal of Religion & Health 55(5):1607 (2016)
Clergy have historically provided 'healing' through various spiritual and medical modalities and even in modern, developed welfare economies they may still be an important help-seeking resource. Partnerships between religion and psychiatry are regularly advocated, but there is scant research on ...
Cardiovascular side effects of psychopharmacologic therapy.
International Journal of Cardiology 219:367 (2016)
WHO defined in 1976 psychopharmaca as drugs affecting psychological functions, behaviour and self-perception. Psychopharmacology is the study of pharmacological agents that affect mental and emotional functions. Creative approach to psychopharmacotherapy reflects a transdisciplinary, integrative...
The relation between chronotype and treatment outcome with light therapy on a fixed time schedule.
Journal of Affective Disorders 202:87 (2016)
Seasonal affective disorder (SAD) is characterized by recurrent episodes of major depression in a seasonal pattern. The therapy of choice is light therapy (LT). It is suggested that LT should be administered relative to the chronotype of the patient, with the optimal timing earlier for morning t...
Increased neuroplasticity and hippocampal microglia activation in a mice model of rapid antidepressant treatment.
Behavioural Brain Research 311:392 (2016)
The search for biomarkers of antidepressant effects focused on pathways regulating synaptic plasticity, and on activated inflammatory markers. Repeated Sleep Deprivation (SD) provides a model treatment to reverse-translate antidepressant effects from in vivo clinical psychiatry to model organism...
Development of fixed dose combination tablets of aripiprazole plus divalproex sodium and their simultaneous determination using HPLC-UV.
Drug Development and Industrial Pharmacy 42(9):1393 (2016)
A vast majority of psychiatric patients are effectively treated with combination of drugs to improve efficacy and adherence, but due to limited research and development in fixed dose combination (FDC) in psychiatry, these products are not commonly available. The aim of this study is to prepare c...
Graphology in German psychiatry (1870-1930).
History of Psychiatry 27(3):307 (2016)
This article discusses both the use of graphology in German psychiatry (1870-1930) and the use of handwriting in psychiatric experiments. The examination of handwriting was part of an ensemble of diagnostic tools. Although disorders of handwriting seemed to indicate psychic diseases, graphology ...
Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit.
Biological Psychiatry 80(5):345 (2016)
Nonhuman primate models are critical for understanding mechanisms underlying human psychopathology. We established a nonhuman primate model of anxious temperament (AT) for studying the early-life risk to develop anxiety and depression. Studies have identified the central nucleus of the amygdala ...
Theory of mind and Verstehen (understanding) methodology.
History of Psychiatry 27(3):253 (2016)
Theory of mind is a prominent, but highly controversial, field in psychology, psychiatry, and philosophy of mind. Simulation theory, theory-theory and other views have been presented in recent decades, none of which are monolithic. In this article, various views on theory of mind are reviewed, a...
Book Review: Gabriel N Mendes, Under the Strain of Color: Harlem's Lafargue Clinic and the Promise of an Antiracist Psychiatry.
History of Psychiatry 27(3):370 (2016)
Managing madness, murderers and paedophiles: Understanding change in the field of English forensic psychiatry.
Social Science & Medicine 164:12 (2016)
This paper discusses changes occurring in the field of English forensic psychiatry which appear to be linked to feelings of discomfort amongst medical professionals who manage care in such settings. These changes are neither the result of a sudden 'shock' to the system, nor small improvisations ...
Pharmacogenomics in Psychiatric Practice.
Clinics in Laboratory Medicine 36(3):507 (2016)
Pharmacogenomic testing in psychiatry is becoming an established clinical procedure. Several vendors provide clinical interpretation of combinatorial pharmacogenomic testing of gene variants that have documented predictive implications regarding either pharmacologic response or adverse effects i...
Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions.
Biological Psychiatry 80(5):356 (2016)
Preclinical models reveal that stress-induced amygdala activity and impairment in fear extinction reflect reductions in anandamide driven by corticotropin-releasing factor receptor type 1 (CRF1) potentiation of the anandamide catabolic enzyme fatty acid amide hydrolase.
Here, we provide clinical...
Frequent daytime naps predict vocabulary growth in early childhood.
Journal of Child Psychology and Psychiatry and ... 57(9):1008 (2016)
The facilitating role of sleep for language learning is well-attested in adults and to a lesser extent in infants and toddlers. However, the longitudinal relationship between sleep patterns and early vocabulary development is not well understood.
This study investigates how measures of sleep are...
Editorial: Bayesian benefits for child psychology and psychiatry researchers.
Journal of Child Psychology and Psychiatry and ... 57(9):985 (2016)
For many scientists, performing statistical tests has become an almost automated routine. However, p-values are frequently used and interpreted incorrectly; and even when used appropriately, p-values tend to provide answers that do not match researchers' questions and hypotheses well. Bayesian s...
The effectiveness and safety of amisulpride in Chinese patients with schizophrenia: An 8-week, prospective, open-label, multicenter, single-arm study.
Asia Pacific Psychiatry 8(3):241 (2016)
This study evaluated the effectiveness and safety of amisulpride in Chinese schizophrenia patients.
A multicenter, single-arm Phase IV study (NCT01795183). Chinese patients with schizophrenia received amisulpride for 8 weeks. The primary endpoint was ≥50% decrease in Positive and Negative Syndro...
Marginal revenue and length of stay in inpatient psychiatry.
The European Journal of Health Economics (HEPAC) 17(7):897 (2016)
This study examines the changes in marginal revenue during psychiatric inpatient stays in a large Swiss psychiatric hospital after the introduction of a mixed reimbursement system with tariff rates that vary over length of stay. A discrete time duration model with a difference-in-difference spec...
Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples.
Journal of Child Psychology and Psychiatry and ... 57(9):1018 (2016)
Neuroimaging methods that allow researchers to investigate structural covariance between brain regions are increasingly being used to study psychiatric disorders. Structural covariance analyses are particularly well suited for studying disorders with putative neurodevelopmental origins as they a...
Pure animal phobia is more specific than other specific phobias: epidemiological evidence from the Zurich Study, the ZInEP and the PsyCoLaus.
European Archives of Psychiatry and Clinical Ne... 266(6):567 (2016)
Interest in subtypes of mental disorders is growing in parallel with continuing research progress in psychiatry. The aim of this study was to examine pure animal phobia in contrast to other specific phobias and a mixed subtype. Data from three representative Swiss community samples were analysed...