Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment.
Progress in Neuro-Psychopharmacology and Biolog... 62:51 (2015)
Kappa opioid receptors (KORs) in the central nervous system have been known to be important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their precise involvement in these disorders is complex and has yet to be fully elucidated. Here, we briefly review th...
Defining and Measuring Spirituality in South African Specialist Psychiatry.
Journal of Religion & Health 54(5):1839 (2015)
To define the meaning of "spirituality" in a South African phenomenological, theory-generating qualitative inquiry, theory construction methodology was used. This refers to the tradition of nursing theory development, where a central core concept identified from the integrated data-in this case,...
Dissociation in bipolar disorder: Relationships between clinical variables and childhood trauma.
Journal of Affective Disorders 184:104 (2015)
The dissociative experiences of patients with bipolar disorder (BD) differ from those of patients with other psychiatric disorders with regard to certain features. The primary goal of this study was to evaluate the relationship between the clinical variables of BD and childhood trauma using the ...
Suicides following inpatient psychiatric hospitalization: A nationwide case control study.
Journal of Affective Disorders 184:164 (2015)
Research shows the elevated risk of suicide associated with current or recent inpatient psychiatric hospitalization. However, it is unclear whether this applies in the area of post-communist Central and Eastern Europe where mental health care has not been deinstitutionalized yet. The present stu...
Writing Prozāk Diaries in Tehran: Generational Anomie and Psychiatric Subjectivities.
Culture, Medicine and Psychiatry 39(3):399 (2015)
I explore the historical and cultural shifts that underlie the normalization of the term dépréshen and the emergence of public psychiatric discourses in 1990s Iran. I do this by investigating the cultural sensibilities of a particular generation, the self-identified 1980s generation, and the way...
On the Social Constructionist Approach to Traumatized Selves in Post-disaster Settings: State-Induced Violence in Nandigram, India.
Culture, Medicine and Psychiatry 39(3):428 (2015)
Through the use of concepts such as traumatization and posttraumatic stress disorder (PTSD), the distressing experiences of survivors are understood in psychology and psychiatry primarily as the behavioural symptoms resulting supposedly from an incomplete emotional and cognitive processing of tr...
Incidental thyroid lesions on FDG-PET/CT: a prevalence study and proposition of management.
Minerva endocrinologica 40(3):169 (2015)
Thyroid incidentaloma is defined as an unsuspected, asymptomatic thyroid lesion that is discovered on an imaging study. The purpose of this study is to determine incidentally identified thyroid lesions by FDG-PET/CT in cancer patients by virtue of preoperative staging and to pay attention how sh...
To Forgive and Discredit: Bipolar Identities and Medicated Selves Among Female Youth in Residential Treatment.
Culture, Medicine and Psychiatry 39(3):505 (2015)
Based on 11 months of ethnographic fieldwork at a residential treatment center in the United States, this article explores the varied meanings that female youth attribute to behavior and the strategic (mis)use of knowledge about psychiatric diagnosis and medication at a time when the scope of be...
Ramelteon as adjunctive therapy for delirium referred to a consultation-liaison psychiatry service: a retrospective analysis.
International Journal of Geriatric Psychiatry 30(9):994 (2015)
Advancing the screening of fibromyalgia in late-life depression: practical implications for psychiatric settings.
International Psychogeriatrics 27(9):1513 (2015)
Fibromyalgia (FM) is common in older adults suffering from mood disorders. However, clinical diagnosis of FM is challenging, particularly in psychiatric settings. We examined the prevalence of FM and the sensitivity of three simple screeners for FM.
Using cross-sectional data, we evaluated three...
Regional gray matter density is associated with morningness-eveningness: Evidence from voxel-based morphometry.
NeuroImage 117:294 (2015)
Diurnal preference (morningness-eveningness) is known to be associated with several individual characteristics that are important in the fields of sociology, education, and psychiatry. Despite this importance, the anatomical correlates of individual differences in morningness-eveningness are unk...
Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in Mice.
Biological Psychiatry 78(4):249 (2015)
Emerging evidence implicates circadian abnormalities as a component of the pathophysiology of major depressive disorder (MDD). The suprachiasmatic nucleus (SCN) of the hypothalamus coordinates rhythms throughout the brain and body. On a cellular level, rhythms are generated by transcriptional, t...
Predicting the Naturalistic Course of Major Depressive Disorder Using Clinical and Multimodal Neuroimaging Information: A Multivariate Pattern Recognition Study.
Biological Psychiatry 78(4):278 (2015)
A chronic course of major depressive disorder (MDD) is associated with profound alterations in brain volumes and emotional and cognitive processing. However, no neurobiological markers have been identified that prospectively predict MDD course trajectories. This study evaluated the prognostic va...
The Anxiolytic and Antidepressant-like Effects of Testosterone and Estrogen in Gonadectomized Male Rats.
Biological Psychiatry 78(4):259 (2015)
While the influence of testosterone levels on vulnerability to affective disorders is not straightforward, research suggests this hormone may confer some degree of resiliency in men. We recently demonstrated a role for the dentate gyrus in mediating testosterone's protective effects on depressiv...
MicroRNA and Posttranscriptional Dysregulation in Psychiatry.
Biological Psychiatry 78(4):231 (2015)
Psychiatric syndromes, including schizophrenia, mood disorders, and autism spectrum disorders, are characterized by a complex range of symptoms, including psychosis, depression, mania, and cognitive deficits. Although the mechanisms driving pathophysiology are complex and remain largely unknown,...
Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience.
Biological Psychiatry 78(4):224 (2015)
The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings s...
Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders.
Biological Psychiatry 78(4):270 (2015)
Persistent cognitive dysfunction in depression and bipolar disorder (BD) impedes patients' functional recovery. Erythropoietin (EPO) increases neuroplasticity and reduces cognitive difficulties in treatment-resistant depression (TRD) and remitted BD. This magnetic resonance imaging study assesse...
A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression.
Biological Psychiatry 78(4):240 (2015)
Multiple open-label trials of deep brain stimulation (DBS) for treatment-resistant depression (TRD), including those targeting the ventral capsule/ventral striatum target, have shown encouraging response rates. However, no randomized controlled trials of DBS for TRD have been published.
Ethics rounds do not improve the handling of ethical issues by psychiatric staff.
Nordic Journal of Psychiatry 69(6):418 (2015)
One way to support healthcare staff in handling ethically difficult situations is through ethics rounds that consist of discussions based on clinical cases and are moderated by an ethicist. Previous research indicates that the handling of ethically difficult situations in the workplace might hav...
Realizing the Potential of Mobile Mental Health: New Methods for New Data in Psychiatry.
Current Psychiatry Reports 17(8):602 (2015)
Smartphones are now ubiquitous and can be harnessed to offer psychiatry a wealth of real-time data regarding patient behavior, self-reported symptoms, and even physiology. The data collected from smartphones meet the three criteria of big data: velocity, volume, and variety. Although these data ...