Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs.
PLoS Genetics 12(3):e1005851 (2016)
Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when identifying loci under selection during dog domestication. To investigate p...
Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.
Genome Research 25(11):1646 (2015)
Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell ...
Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test.
Molecular Cancer Research 13(6):993 (2015)
Targeted cancer therapies offer great clinical promise, but treatment resistance is common, and basic research aimed at overcoming this challenge is limited by reduced genomic and biologic complexity in artificially induced rodent tumors compared with their human counterparts. Animal models that...
Cancer. Hiding in plain view--an ancient dog in the modern world.
Science 343(6169):376 (2014)
Genome sequencing highlights the dynamic early history of dogs.
PLoS Genetics 10(1):e1004016 (2014)
To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden ...
A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.
PLoS Genetics 9(3):e1003409 (2013)
The domestic dog is a robust model for studying the genetics of complex disease susceptibility. The strategies used to develop and propagate modern breeds have resulted in an elevated risk for specific diseases in particular breeds. One example is that of Standard Poodles (STPOs), who have incre...
Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping.
Mammalian Genome 24(1-2):80 (2013)
The ability to detect recent hybridization between dogs and wolves is important for conservation and legal actions, which often require accurate and rapid resolution of ancestry. The availability of a genetic test for dog-wolf hybrids would greatly support federal and legal enforcement efforts, ...
Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis.
Journal of Heredity 104(3):399 (2013)
The causative mutation for the black-and-tan (a (t) ) phenotype in dogs was previously shown to be a SINE insertion in the 5' region of Agouti Signaling Protein (ASIP). Dogs with the black-and-tan phenotype, as well as dogs with the saddle tan phenotype, genotype as a (t) /_ at this locus. We ha...
Telomere length correlates with life span of dog breeds.
Cell Reports 2(6):1530 (2012)
Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence. Some studies have indicated that telomere length correlates with mortality, suggesting that telomere length contributes to...
The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.
Cancer Epidemiology Biomarkers & Prevention 21(7):1019 (2012)
Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human families or populations are of particular interest. Histioc...
Myxomatous mitral valve disease in dogs: does size matter?
Journal of Veterinary Cardiology 14(1):19 (2012)
Myxomatous mitral valve disease (MMVD) is the most commonly diagnosed cardiovascular disease in the dog accounting for more than 70% of all cardiovascular disease in dogs. As are most canine diseases with genetic underpinnings, risk of MMVD is greatly increased in a subset of breeds. What is unc...
Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs.
Mammalian Genome 23(1-2):178 (2012)
Alaskan sled dogs are a genetically distinct population shaped by generations of selective interbreeding with purebred dogs to create a group of high-performance athletes. As a result of selective breeding strategies, sled dogs present a unique opportunity to employ admixture-mapping techniques ...
Genomic analyses of modern dog breeds.
Mammalian Genome 23(1-2):19 (2012)
A rose may be a rose by any other name, but when you call a dog a poodle it becomes a very different animal than if you call it a bulldog. Both the poodle and the bulldog are examples of dog breeds of which there are >400 recognized worldwide. Breed creation has played a significant role in shap...
Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug development.
The Journal of Urology 187(1):302 (2012)
We determined the efficacy, biological activity, pharmacokinetics and safety of the hypomethylating agent 5-azacitidine (Celgene Corp., Summit, New Jersey) in dogs with naturally occurring invasive urothelial carcinoma.
We performed a preclinical phase I trial in dogs with naturally occurring in...
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication.
Nature 464(7290):898 (2010)
Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dog diversification better, we conducted an extensive genome-wide survey of more than 48,000 single n...
A genetic dissection of breed composition and performance enhancement in the Alaskan sled dog.
BMC Genetics 11:71 (2010)
The Alaskan sled dog offers a rare opportunity to investigate the development of a dog breed based solely on performance, rather than appearance, thus setting the breed apart from most others. Several established breeds, many of which are recognized by the American Kennel Club (AKC), have been i...
An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog.
Journal of Heredity 101(5):612 (2010)
We recently showed that genes at 3 loci account for the majority of variation in canine fur. Allelic variation at genes controlling length of fur, texture, and curl is responsible for the striking phenotypic variety observed among purebred dogs in the United States today. In this paper, we inves...
Man's best friend becomes biology's best in show: genome analyses in the domestic dog.
Genetics 44:309 (2010)
In the last five years, canine genetics has gone from map construction to complex disease deconstruction. The availability of a draft canine genome sequence, dense marker chips, and an understanding of the genome architecture has changed the types of studies canine geneticists can undertake. The...
A simple genetic architecture underlies morphological variation in dogs.
PLoS Biology 8(8):e1000451 (2010)
Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal. Here, we generate a high density map of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10 outbred African shelter...
Coat variation in the domestic dog is governed by variants in three genes.
Science 326(5949):150 (2009)
Coat color and type are essential characteristics of domestic dog breeds. Although the genetic basis of coat color has been well characterized, relatively little is known about the genes influencing coat growth pattern, length, and curl. We performed genome-wide association studies of more than ...