1. Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer-Evidence for a Relevant Model System and Urine-Based Diagnostic Test.

    Molecular Cancer Research 13(6):993 (2015) PMID 25767210 PMCID PMC4470794

    Targeted cancer therapies offer great clinical promise, but treatment resistance is common, and basic research aimed at overcoming this challenge is limited by reduced genomic and biologic complexity in artificially induced rodent tumors compared with their human counterparts. Animal models that...
  2. Cancer. Hiding in plain view--an ancient dog in the modern world.

    Science 343(6169):376 (2014) PMID 24458629

  3. Cancer. Hiding in plain view--an ancient dog in the modern world.

    Science 343(6169):376 (2014) PMID 24458629

  4. Genome sequencing highlights the dynamic early history of dogs.

    PLoS Genetics 10(1):e1004016 (2014) PMID 24453982 PMCID PMC3894170

    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden ...
  5. Genome sequencing highlights the dynamic early history of dogs.

    PLoS Genetics 10(1):e1004016 (2014) PMID 24453982 PMCID PMC3894170

    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden ...
  6. Genome sequencing highlights the dynamic early history of dogs.

    PLoS Genetics 10(1):e1004016 (2014) PMID 24453982 PMCID PMC3894170

    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden ...
  7. A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.

    PLoS Genetics 9(3):e1003409 (2013) PMID 23555311 PMCID PMC3610924

    The domestic dog is a robust model for studying the genetics of complex disease susceptibility. The strategies used to develop and propagate modern breeds have resulted in an elevated risk for specific diseases in particular breeds. One example is that of Standard Poodles (STPOs), who have incre...
  8. A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit.

    PLoS Genetics 9(3):e1003409 (2013) PMID 23555311 PMCID PMC3610924

    The domestic dog is a robust model for studying the genetics of complex disease susceptibility. The strategies used to develop and propagate modern breeds have resulted in an elevated risk for specific diseases in particular breeds. One example is that of Standard Poodles (STPOs), who have incre...
  9. Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping.

    Mammalian Genome 24(1-2):80 (2013) PMID 23064780

    The ability to detect recent hybridization between dogs and wolves is important for conservation and legal actions, which often require accurate and rapid resolution of ancestry. The availability of a genetic test for dog-wolf hybrids would greatly support federal and legal enforcement efforts, ...
  10. Identification of recent hybridization between gray wolves and domesticated dogs by SNP genotyping.

    Mammalian Genome 24(1-2):80 (2013) PMID 23064780

    The ability to detect recent hybridization between dogs and wolves is important for conservation and legal actions, which often require accurate and rapid resolution of ancestry. The availability of a genetic test for dog-wolf hybrids would greatly support federal and legal enforcement efforts, ...
  11. Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis.

    Journal of Heredity 104(3):399 (2013) PMID 23519866

    The causative mutation for the black-and-tan (a (t) ) phenotype in dogs was previously shown to be a SINE insertion in the 5' region of Agouti Signaling Protein (ASIP). Dogs with the black-and-tan phenotype, as well as dogs with the saddle tan phenotype, genotype as a (t) /_ at this locus. We ha...
  12. Telomere Length Correlates with Life Span of Dog Breeds

    Cell Reports 2(6):1530 (2012)

    Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence. Some studies have indicated that telomere length correlates with mortality, suggesting that telomere length cont...
  13. Telomere length correlates with life span of dog breeds.

    Cell Reports 2(6):1530 (2012) PMID 23260664

    Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence. Some studies have indicated that telomere length correlates with mortality, suggesting that telomere length contributes to...
  14. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.

    Cancer Epidemiology Biomarkers & Prevention 21(7):1019 (2012) PMID 22623710 PMCID PMC3392365

    Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human families or populations are of particular interest. Histioc...
  15. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer.

    Cancer Epidemiology Biomarkers & Prevention 21(7):1019 (2012) PMID 22623710 PMCID PMC3392365

    Advantages offered by canine population substructure, combined with clinical presentations similar to human disorders, makes the dog an attractive system for studies of cancer genetics. Cancers that have been difficult to study in human families or populations are of particular interest. Histioc...
  16. Myxomatous mitral valve disease in dogs: Does size matter?

    Journal of Veterinary Cardiology 14(1):19 (2012)

    Myxomatous mitral valve disease (MMVD) is the most commonly diagnosed cardiovascular disease in the dog accounting for more than 70% of all cardiovascular disease in dogs. As are most canine diseases with genetic underpinnings, risk of MMVD is greatly increased in a subset of breeds. W...
  17. Myxomatous mitral valve disease in dogs: does size matter?

    Journal of Veterinary Cardiology 14(1):19 (2012) PMID 22356836 PMCID PMC3307894

    Myxomatous mitral valve disease (MMVD) is the most commonly diagnosed cardiovascular disease in the dog accounting for more than 70% of all cardiovascular disease in dogs. As are most canine diseases with genetic underpinnings, risk of MMVD is greatly increased in a subset of breeds. What is unc...
  18. Myxomatous mitral valve disease in dogs: does size matter?

    Journal of Veterinary Cardiology 14(1):19 (2012) PMID 22356836 PMCID PMC3307894

    Myxomatous mitral valve disease (MMVD) is the most commonly diagnosed cardiovascular disease in the dog accounting for more than 70% of all cardiovascular disease in dogs. As are most canine diseases with genetic underpinnings, risk of MMVD is greatly increased in a subset of breeds. What is unc...
  19. Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs.

    Mammalian Genome 23(1-2):178 (2012) PMID 22105876 PMCID PMC3320045

    Alaskan sled dogs are a genetically distinct population shaped by generations of selective interbreeding with purebred dogs to create a group of high-performance athletes. As a result of selective breeding strategies, sled dogs present a unique opportunity to employ admixture-mapping techniques ...
  20. Genomic analyses of modern dog breeds.

    Mammalian Genome 23(1-2):19 (2012) PMID 22231497 PMCID PMC3559126

    A rose may be a rose by any other name, but when you call a dog a poodle it becomes a very different animal than if you call it a bulldog. Both the poodle and the bulldog are examples of dog breeds of which there are >400 recognized worldwide. Breed creation has played a significant role in shap...