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  1. Astrocyte-derived ATP modulates depressive-like behaviors.
    Xiong Cao, Liang-Ping Li, ... Tian-Ming Gao

    Nat Med (2013) PMID 23644515

    We identified ATP as a key factor involved in astrocytic modulation of depressive-like behavior in adult mice. We observed low ATP abundance in the brains of mice that were susceptible to chronic social defeat. Furthermore, we found that the administration of ATP induced a rapid antidepressant-like...
  2. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.
    Paul F Robbins, Yong-Chen Lu, ... Steven A Rosenberg

    Nat Med (2013) PMID 23644516

    We developed a new screening approach involving mining whole-exome sequence data to identify mutated proteins expressed in patient tumors. We then synthesized and evaluated candidate mutated T cell epitopes that were identified using a major histocompatibility complex-binding algorithm for recogniti...
  3. Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.
    Daniel Lucas, Christoph Scheiermann, ... Paul S Frenette

    Nat Med (2013) PMID 23644514

    We demonstrate that chemotherapy-induced nerve injury in the bone marrow of mice is a crucial lesion impairing hematopoietic regeneration. Using pharmacological and genetic models, we show that the selective loss of adrenergic innervation in the bone marrow alters its regeneration after genotoxic in...
  4. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.
    Nicola Gagliani, Chiara F Magnani, ... Maria-Grazia Roncarolo

    Nat Med (2013) PMID 23624599

    We identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healt...
  5. A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity.
    Dmitri Lodygin, Francesca Odoardi, ... Alexander Flügel

    Nat Med (2013) PMID 23624600

    We combined fluorescently labeled nuclear factor of activated T cells (NFAT) with histone protein H2B to create a broadly applicable molecular sensor for intravital imaging of T cell activation. In experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis, we report that effe...
  6. A colorectal cancer classification system that associates cellular phenotype and responses to therapy.
    Anguraj Sadanandam, Costas A Lyssiotis, ... Douglas Hanahan

    Nat Med (2013) PMID 23584089

    We analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six...
  7. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.
    Andrew J Murphy, Nora Bijl, ... Nan Wang

    Nat Med (2013) PMID 23584088

    We show that transplantation of bone marrow deficient in ABCG4, a transporter of unknown function, into Ldlr(-/-) mice resulted in thrombocytosis, accelerated thrombosis and atherosclerosis. Although not detected in atherosclerotic lesions, Abcg4 was highly expressed in bone marrow megakaryocyte pro...
  8. Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
    Felipe De Sousa E Melo, Xin Wang, ... Louis Vermeulen

    Nat Med (2013) PMID 23584090

    We demonstrate, using an unsupervised classification strategy involving over 1,100 individuals with colon cancer, that three main molecularly distinct subtypes can be recognized. Two subtypes have been previously identified and are well characterized (chromosomal-instable and microsatellite-instable...
  9. Regeneration and experimental orthotopic transplantation of a bioengineered kidney.
    Jeremy J Song, Jacques P Guyette, ... Harald C Ott

    Nat Med (2013) PMID 23584091

    We decellularized rat, porcine and human kidneys by detergent perfusion, yielding acellular scaffolds with vascular, cortical and medullary architecture, a collecting system and ureters. To regenerate functional tissue, we seeded rat kidney scaffolds with epithelial and endothelial cells and perfuse...
  10. New from NPG.
    Author(s) unavailable

    Nat Med 19(4):417 (2013) PMID 23558637