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Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGF-β-TAK1-Dependent Mechanism.
PLoS Biol 11(4):e1001527 (2013) PMID 23565059
We show that homeodomain interacting protein kinases, HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-β-dependent angiogenesis during embryonic development. Loss of HIPK1 and HIPK2 leads to marked up-regulations of several potent angiogenic genes, including Mmp10 and Vegf, which... -
Insights into how calcium forms plaques in arteries pave the way for new treatments for heart disease.
PLoS Biol 11(4):e1001533 (2013) PMID 23585734
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An introduction to social media for scientists.
PLoS Biol 11(4):e1001535 (2013) PMID 23630451
Online social media tools can be some of the most rewarding and informative resources for scientists-IF you know how to use them. -
Subcellular localization determines the stability and axon protective capacity of axon survival factor nmnat2.
PLoS Biol 11(4):e1001539 (2013) PMID 23610559
We investigate the mechanism of fast axonal transport of Nmnat2 and its site of action for axon maintenance. Using dual-colour live-cell imaging of axonal transport in SCG primary culture neurons, we find that Nmnat2 is bidirectionally trafficked in axons together with markers of the trans-Golgi net... -
PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance.
PLoS Biol 11(4):e1001542 (2013) PMID 23630454
We identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting with C kinase 1) as a key component early in the biogenesis of secretory vesicles in GH-producing cells. Both PICK1-deficient Drosophila and mice displayed somatic growth retardation. Growth retardation... -
A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta.
PLoS Biol 11(4):e1001536 (2013) PMID 23610556
We demonstrate here that an amplifying signaling loop between Gcm1 and Fzd5 is essential for normal initiation of branching in the chorionic plate. While Gcm1 upregulates Fzd5 specifically at sites where branching initiates in the basal chorion, this elevated Fzd5 expression via nuclear β-catenin s... -
Feedback between Population and Evolutionary Dynamics Determines the Fate of Social Microbial Populations.
PLoS Biol 11(4):e1001547 (2013) PMID 23637571
We demonstrate the presence of a strong feedback loop between population dynamics and the evolutionary dynamics of a social microbial gene, SUC2, in laboratory yeast populations whose cooperative growth is mediated by the SUC2 gene. We directly visualize eco-evolutionary trajectories of hundreds of... -
Synthetic biology and conservation of nature: wicked problems and wicked solutions.
PLoS Biol 11(4):e1001530 (2013) PMID 23565062
So far, conservation scientists have paid little attention to synthetic biology; this is unfortunate as the technology is likely to transform the operating space within which conservation functions, and therefore the prospects for maintaining biodiversity into the future.... -
Synthesis of very-long-chain Fatty acids in the epidermis controls plant organ growth by restricting cell proliferation.
PLoS Biol 11(4):e1001531 (2013) PMID 23585732
We found that VLCFA synthesis in the epidermis is essential for proper development of Arabidopsis thaliana. Wild-type plants treated with a VLCFA synthesis inhibitor and pasticcino mutants with defects in VLCFA synthesis exhibited overproliferation of cells in the vasculature or in the rib zone of s... -
HIV Plays (and Wins) a Game of T Cell Brinkmanship.
PLoS Biol 11(4):e1001521 (2013) PMID 23565056
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