1. Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing.

    BMC Biotechnology 14:36 (2014) PMID 24886511 PMCID PMC4021294

    The zebrafish has been established as the main vertebrate model system for whole organism screening applications. However, the lack of consistent positioning of zebrafish embryos within wells of microtiter plates remains an obstacle for the comparative analysis of images acquired in automated sc...
  2. Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing.

    BMC Biotechnology 14:36 (2014) PMID 24886511 PMCID PMC4021294

    The zebrafish has been established as the main vertebrate model system for whole organism screening applications. However, the lack of consistent positioning of zebrafish embryos within wells of microtiter plates remains an obstacle for the comparative analysis of images acquired in automated sc...
  3. Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing.

    BMC Biotechnology 14:36 (2014) PMID 24886511 PMCID PMC4021294

    The zebrafish has been established as the main vertebrate model system for whole organism screening applications. However, the lack of consistent positioning of zebrafish embryos within wells of microtiter plates remains an obstacle for the comparative analysis of images acquired in automated sc...
  4. Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney.

    PLoS ONE 8(12):e82137 (2013) PMID 24324758 PMCID PMC3852951

    The analysis of kidney malformation caused by environmental influences during nephrogenesis or by hereditary nephropathies requires animal models allowing the in vivo observation of developmental processes. The zebrafish has emerged as a useful model system for the analysis of vertebrate organ d...
  5. Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney.

    PLoS ONE 8(12):e82137 (2013) PMID 24324758 PMCID PMC3852951

    The analysis of kidney malformation caused by environmental influences during nephrogenesis or by hereditary nephropathies requires animal models allowing the in vivo observation of developmental processes. The zebrafish has emerged as a useful model system for the analysis of vertebrate organ d...
  6. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.

    Trends in Biotechnology 30(8):421 (2012) PMID 22652049 PMCID PMC3401323

    For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are changing ...
  7. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology

    Trends in Biotechnology 30(8):421 (2012)

    For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are...
  8. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology

    Trends in Biotechnology 30(8):421 (2012) PMID 22652049 PMCID PMC3401323

    For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are...
  9. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology

    Trends in Biotechnology 30(8):421 (2012) PMID 22652049 PMCID PMC3401323

    For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are...
  10. Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology

    Trends in Biotechnology 30(8):421 (2012) PMID 22652049 PMCID PMC3401323

    For decades, studying the behavioral effects of individual drugs and genetic mutations has been at the heart of efforts to understand and treat nervous system disorders. High-throughput technologies adapted from other disciplines (e.g., high-throughput chemical screening, genomics) are...
  11. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells.

    Archives of Toxicology 86(2):329 (2012) PMID 21983885

    Polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants formed during incomplete combustion of organic material. For example benzo[a]pyrene (B[a]P) is a constituent and contaminant of cigarette smoke, automobile exhaust, industrial waste and even food products. B[a]P is carcinog...
  12. Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells.

    Archives of Toxicology 86(2):329 (2012) PMID 21983885

    Polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants formed during incomplete combustion of organic material. For example benzo[a]pyrene (B[a]P) is a constituent and contaminant of cigarette smoke, automobile exhaust, industrial waste and even food products. B[a]P is carcinog...
  13. Facilitating drug discovery: an automated high-content inflammation assay in zebrafish.

    Journal of Visualized Experiments (65):e4203 (2012) PMID 22825322 PMCID PMC3476412

    Zebrafish larvae are particularly amenable to whole animal small molecule screens due to their small size and relative ease of manipulation and observation, as well as the fact that compounds can simply be added to the bathing water and are readily absorbed when administered in a <1% DMSO soluti...
  14. Superhydrophobic-superhydrophilic micropatterning: towards genome-on-a-chip cell microarrays.

    Angewandte Chemie. International edition in Eng... 50(36):8424 (2011) PMID 21751312

  15. Superhydrophobic-superhydrophilic micropatterning: towards genome-on-a-chip cell microarrays.

    Angewandte Chemie. International edition in Eng... 50(36):8424 (2011) PMID 21751312

  16. 'Sciencenet'--towards a global search and share engine for all scientific knowledge.

    PMID 21493657 PMCID PMC3106183

    Modern biological experiments create vast amounts of data which are geographically distributed. These datasets consist of petabytes of raw data and billions of documents. Yet to the best of our knowledge, a search engine technology that searches and cross-links all different data types in life s...
  17. 'Sciencenet'--towards a global search and share engine for all scientific knowledge.

    PMID 21493657 PMCID PMC3106183

    Modern biological experiments create vast amounts of data which are geographically distributed. These datasets consist of petabytes of raw data and billions of documents. Yet to the best of our knowledge, a search engine technology that searches and cross-links all different data types in life s...
  18. Automated feature detection and imaging for high-resolution screening of zebrafish embryos.

    BioTechniques 50(5):319 (2011) PMID 21548893

    The development of automated microscopy platforms has enabled large-scale observation of biological processes, thereby complementing genome scale biochemical techniques. However, commercially available systems are restricted either by fixed-field-of-views, leading to potential omission of featur...
  19. Automated feature detection and imaging for high-resolution screening of zebrafish embryos.

    BioTechniques 50(5):319 (2011) PMID 21548893

    The development of automated microscopy platforms has enabled large-scale observation of biological processes, thereby complementing genome scale biochemical techniques. However, commercially available systems are restricted either by fixed-field-of-views, leading to potential omission of featur...
  20. Image-based fluidic sorting system for automated Zebrafish egg sorting into multiwell plates.

    Journal of Laboratory Automation 16(2):105 (2011) PMID 21609691

    The global demand for the reduction of animal testing has led to the emergence of Zebrafish eggs/larvae as model organisms to replace current adult animal testing in, for example, toxicity testing. Because of the egg size (diameter 1.6mm) and the relatively easy maintenance of Zebrafish farms th...